1sp4

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{{STRUCTURE_1sp4| PDB=1sp4 | SCENE= }}
{{STRUCTURE_1sp4| PDB=1sp4 | SCENE= }}
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'''Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft'''
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===Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft===
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==Overview==
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The crystal structure of the inhibitor NS-134 in complex with bovine cathepsin B reveals that functional groups attached to both sides of the epoxysuccinyl reactive group bind to the part of active-site cleft as predicted. The -Leu-Pro-OH side binds to the primed binding sites interacting with the His110 and His111 residues with its C-terminal carboxy group, whereas the -Leu-Gly-Meu (-Leu-Gly-Gly-OMe) part (Meu, methoxycarbonylmethyl) binds along the non-primed binding sites. Comparison with the propeptide structures of cathepsins revealed that the binding of the latter part is least similar to the procathepsin B structure; this result, together with the two-residue shift in positioning of the Leu-Gly-Gly part, suggests that the propeptide structures of the cognate enzymes may not be the best starting point for the design of reverse binding inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15084146}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15084146 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15084146}}
==About this Structure==
==About this Structure==
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[[Category: Epoxysuccinyl-based inhibitor]]
[[Category: Epoxysuccinyl-based inhibitor]]
[[Category: Inhibitor design]]
[[Category: Inhibitor design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:58:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:26:46 2008''

Revision as of 17:26, 27 July 2008

Image:1sp4.png

Template:STRUCTURE 1sp4

Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft

Template:ABSTRACT PUBMED 15084146

About this Structure

1SP4 is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft., Stern I, Schaschke N, Moroder L, Turk D, Biochem J. 2004 Jul 15;381(Pt 2):511-7. PMID:15084146

Page seeded by OCA on Sun Jul 27 20:26:46 2008

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