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1kq8

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(New page: 200px<br /><applet load="1kq8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kq8" /> '''Solution Structure of Winged Helix Protein H...)
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Revision as of 17:30, 20 November 2007

Image:1kq8.jpg

1kq8

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Solution Structure of Winged Helix Protein HFH-1

Overview

The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) family contains a, large number of transcription factors that recognize divergent DNA, sequences via a winged helix binding motif. HNF-3/fkh proteins show a, broad profile of DNA sequence-specificity in which one DNA sequence can be, recognized by more than one HNF-3/fkh protein and each individual, HNF-3/fkh protein has several DNA binding sequences. In this study, heteronuclear NMR methods were used to study the structures of the DNA, binding domain of a conserved winged helix protein HFH-1 and its DNA, complexes. The structural comparison of winged helix proteins HFH-1 and, Genesis and their DNA complexes indicates that even two highly conserved, HNF-3 family members can adopt different local structures when they, contact an identical DNA binding sequence, while one of these two HNF-3, proteins seems to adopt only slightly different structures on different, DNA binding sites.

About this Structure

1KQ8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:11876636

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