2f4t

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{{Seed}}
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{{STRUCTURE_2f4t| PDB=2f4t | SCENE= }}
{{STRUCTURE_2f4t| PDB=2f4t | SCENE= }}
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'''Asite RNA + designer antibiotic'''
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===Asite RNA + designer antibiotic===
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==Overview==
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The X-ray crystal structures for the complexes of three designer antibiotics, compounds 1, 2, and 3, bound to two models for the ribosomal aminoacyl-tRNA site (A site) at 2.5-3.0 Angstroms resolution and that of neamine at 2.8 Angstroms resolution are described. Furthermore, the complex of antibiotic 1 bound to the A site in the entire 30S ribosomal subunit of Thermus thermophilus is reported at 3.8 Angstroms resolution. Molecular dynamics simulations revealed that the designer compounds provide additional stability to bases A1492 and A1493 in their extrahelical forms. Snapshots from the simulations were used for free energy calculations, which revealed that van der Waals and hydrophobic effects were the driving forces behind the binding of designer antibiotic 3 when compared to the parental neamine.
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(as it appears on PubMed at http://www.pubmed.gov), where 16492561 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16492561}}
==About this Structure==
==About this Structure==
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[[Category: Asite rna]]
[[Category: Asite rna]]
[[Category: Designer antibiotic]]
[[Category: Designer antibiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:27:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:30:09 2008''

Revision as of 17:30, 27 July 2008

Image:2f4t.png

Template:STRUCTURE 2f4t

Asite RNA + designer antibiotic

Template:ABSTRACT PUBMED 16492561

About this Structure

Full crystallographic information is available from OCA.

Reference

Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site., Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S, Chem Biol. 2006 Feb;13(2):129-38. PMID:16492561

Page seeded by OCA on Sun Jul 27 20:30:09 2008

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