1tvk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tvk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1tvk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tvk| PDB=1tvk | SCENE= }}
{{STRUCTURE_1tvk| PDB=1tvk | SCENE= }}
-
'''The binding mode of epothilone A on a,b-tubulin by electron crystallography'''
+
===The binding mode of epothilone A on a,b-tubulin by electron crystallography===
-
==Overview==
+
<!--
-
The structure of epothilone A, bound to alpha,beta-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance-based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding expectation of a common pharmacophore is not met, because each ligand exploits the tubulin-binding pocket in a unique and independent manner.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15297674}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15297674 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15297674}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Ligand interaction]]
[[Category: Ligand interaction]]
[[Category: Taxol]]
[[Category: Taxol]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:25:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:30:38 2008''

Revision as of 17:30, 27 July 2008

Image:1tvk.png

Template:STRUCTURE 1tvk

The binding mode of epothilone A on a,b-tubulin by electron crystallography

Template:ABSTRACT PUBMED 15297674

About this Structure

1TVK is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:15297674

Page seeded by OCA on Sun Jul 27 20:30:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tvk"
Personal tools