2qp2

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{{STRUCTURE_2qp2| PDB=2qp2 | SCENE= }}
{{STRUCTURE_2qp2| PDB=2qp2 | SCENE= }}
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'''Structure of a MACPF/perforin-like protein'''
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===Structure of a MACPF/perforin-like protein===
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==Overview==
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Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-infected cells, respectively. However, the mechanism of MACPF function is unknown. We determined the crystal structure of a bacterial MACPF protein, Plu-MACPF from Photorhabdus luminescens, to 2.0 angstrom resolution. The MACPF domain reveals structural similarity with poreforming cholesterol-dependent cytolysins (CDCs) from Gram-positive bacteria. This suggests that lytic MACPF proteins may use a CDC-like mechanism to form pores and disrupt cell membranes. Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.
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(as it appears on PubMed at http://www.pubmed.gov), where 17717151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17717151}}
==About this Structure==
==About this Structure==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:31:14 2008''

Revision as of 17:31, 27 July 2008

Image:2qp2.png

Template:STRUCTURE 2qp2

Structure of a MACPF/perforin-like protein

Template:ABSTRACT PUBMED 17717151

About this Structure

2QP2 is a Single protein structure of sequence from Photorhabdus luminescens subsp. laumondii. Full crystallographic information is available from OCA.

Reference

A common fold mediates vertebrate defense and bacterial attack., Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC, Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23. PMID:17717151

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