2rmc

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{{STRUCTURE_2rmc| PDB=2rmc | SCENE= }}
{{STRUCTURE_2rmc| PDB=2rmc | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A'''
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===CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A===
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==Overview==
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Cyclophilin is a cellular receptor for the immunosuppressive drug cyclosporin A (CsA). Cyclophilin C (CyPC) is highly expressed in murine kidney, making it a potential mediator of the nephrotoxic effects of CsA. The structure of murine CyPC complexed with CsA has been solved and refined to an R factor of 0.197 at a 1.64-A resolution. Superposition of the CyPC-CsA structure with the unligated cyclophilin A (CyPA) revealed significant migration of three loops: Gln-179 to Thr-189, Asp-47 to Lys-49, and Met-170 to Ile-176. The proximity of the loop Gln-179 to Thr-189 to the CsA binding site may account for the unique binding of a 77-kDa glycoprotein, CyPC binding protein (CyCAP), to CyPC. The binding of CsA to CyPC is similar to that of CsA to human T-cell cyclophilin A (CyPA). However, the conformation of CsA when bound to CyPC is significantly different from that when bound to CyPA. These differences may reflect conformational variation of CsA when bound to different proteins. Alternatively, the previous CyPA-CsA structure at low resolution may not provide sufficient details for a comparison with the CyPC-CsA structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 8265636 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8265636}}
==About this Structure==
==About this Structure==
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[[Category: Weissman, I.]]
[[Category: Weissman, I.]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:31:18 2008''

Revision as of 17:31, 27 July 2008

Image:2rmc.png

Template:STRUCTURE 2rmc

CRYSTAL STRUCTURE OF MURINE CYCLOPHILIN C COMPLEXED WITH IMMUNOSUPPRESSIVE DRUG CYCLOSPORIN A

Template:ABSTRACT PUBMED 8265636

About this Structure

2RMC is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A., Ke H, Zhao Y, Luo F, Weissman I, Friedman J, Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11850-4. PMID:8265636

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