2irv

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[[Image:2irv.gif|left|200px]]
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{{STRUCTURE_2irv| PDB=2irv | SCENE= }}
{{STRUCTURE_2irv| PDB=2irv | SCENE= }}
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'''Crystal structure of GlpG, a rhomboid intramembrane serine protease'''
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===Crystal structure of GlpG, a rhomboid intramembrane serine protease===
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==Overview==
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Intramembrane proteases catalyze peptide bond cleavage of integral membrane protein substrates. This activity is crucial for many biological and pathological processes. Rhomboids are evolutionarily widespread intramembrane serine proteases. Here, we present the 2.3-A-resolution crystal structure of a rhomboid from Escherichia coli. The enzyme has six transmembrane helices, five of which surround a short TM4, which starts deep within the membrane at the catalytic serine residue. Thus, the catalytic serine is in an externally exposed cavity, which provides a hydrophilic environment for proteolysis. Our results reveal a mechanism to enable water-dependent catalysis at the depth of the hydrophobic milieu of the membrane and suggest how substrates gain access to the sequestered rhomboid active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 17190827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17190827}}
==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Ser-his dyad]]
[[Category: Ser-his dyad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:47:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:34:01 2008''

Revision as of 17:34, 27 July 2008

Image:2irv.png

Template:STRUCTURE 2irv

Crystal structure of GlpG, a rhomboid intramembrane serine protease

Template:ABSTRACT PUBMED 17190827

About this Structure

2IRV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for intramembrane proteolysis by rhomboid serine proteases., Ben-Shem A, Fass D, Bibi E, Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):462-6. Epub 2006 Dec 26. PMID:17190827

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