2bau

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[[Image:2bau.gif|left|200px]]
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{{STRUCTURE_2bau| PDB=2bau | SCENE= }}
{{STRUCTURE_2bau| PDB=2bau | SCENE= }}
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'''Solution NMR structure of the micelle-bound myristoylated N-terminal Arf6'''
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===Solution NMR structure of the micelle-bound myristoylated N-terminal Arf6===
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==Overview==
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Arf proteins are guanine nucleotide binding proteins that are implicated in endocytotic pathways and vesicle trafficking. The two widely studied isoforms of Arf proteins (Arf1 and Arf6) have different cellular functions and localizations but similar structures. Arf proteins have an N-terminal helix with a covalently bound myristoyl group. Except structural models, there are no three dimensional structures of the myristoylated N-terminal peptide or the intact myristoylated Arf proteins. However, understanding the role of both the myristoyl group and the N-terminal helix based on the details of their molecular structures is of great interest. In the solution structure of myristoylated N-terminal peptide of Arf6 described here, the myristoyl group folds toward the N-terminus to interact with the hydrophobic residues in particular, the phenyl ring. Also, the structure of the dodecylphosphocholine (DPC) micelle-bound of the peptide together with paramagnetic studies showed that the myristoyl group is inserted into the micelle while residues V4-G10 interact with the surface of the micelle. The structural differences between the unbound and micelle-bound myristoylated N-terminal peptide of Arf6 involves the myristoyl group and the side chains of the hydrophobic residues.
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(as it appears on PubMed at http://www.pubmed.gov), where 16839550 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16839550}}
==About this Structure==
==About this Structure==
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2BAU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAU OCA].
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2BAU is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAU OCA].
==Reference==
==Reference==
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[[Category: Micelle-bound]]
[[Category: Micelle-bound]]
[[Category: Myristoylated peptide]]
[[Category: Myristoylated peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:03:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:35:19 2008''

Revision as of 17:35, 27 July 2008

Image:2bau.png

Template:STRUCTURE 2bau

Solution NMR structure of the micelle-bound myristoylated N-terminal Arf6

Template:ABSTRACT PUBMED 16839550

About this Structure

2BAU is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structural studies of the myristoylated N-terminus of ADP ribosylation factor 6 (Arf6)., Gizachew D, Oswald R, FEBS Lett. 2006 Jul 24;580(17):4296-301. Epub 2006 Jul 7. PMID:16839550

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