2exy

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[[Image:2exy.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2exy| PDB=2exy | SCENE= }}
{{STRUCTURE_2exy| PDB=2exy | SCENE= }}
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'''Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions'''
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===Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions===
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==Overview==
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The ClC channels are members of a large protein family of chloride (Cl-) channels and secondary active Cl- transporters. Despite their diverse functions, the transmembrane architecture within the family is conserved. Here we present a crystallographic study on the ion-binding properties of the ClC selectivity filter in the close homolog from Escherichia coli (EcClC). The ClC selectivity filter contains three ion-binding sites that bridge the extra- and intracellular solutions. The sites bind Cl- ions with mM affinity. Despite their close proximity within the filter, the three sites can be occupied simultaneously. The ion-binding properties are found conserved from the bacterial transporter EcClC to the human Cl- channel ClC-1, suggesting a close functional link between ion permeation in the channels and active transport in the transporters. In resemblance to K+ channels, ions permeate the ClC channel in a single file, with mutual repulsion between the ions fostering rapid conduction.
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(as it appears on PubMed at http://www.pubmed.gov), where 16341087 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16341087}}
==About this Structure==
==About this Structure==
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[[Category: H+/cl- antiporter]]
[[Category: H+/cl- antiporter]]
[[Category: Membrane protein/fab complex]]
[[Category: Membrane protein/fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:14:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:38:39 2008''

Revision as of 17:38, 27 July 2008

Image:2exy.png

Template:STRUCTURE 2exy

Crystal structure of the E148Q Mutant of EcClC, Fab complexed in absence of bound ions

Template:ABSTRACT PUBMED 16341087

About this Structure

2EXY is a Single protein structure of sequence from Escherichia coli and Mus musculus. Full crystallographic information is available from OCA.

Reference

Ion-binding properties of the ClC chloride selectivity filter., Lobet S, Dutzler R, EMBO J. 2006 Jan 11;25(1):24-33. Epub 2005 Dec 8. PMID:16341087

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