1kqf

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Revision as of 17:31, 20 November 2007

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spinqualitylabelsall models 1kqf, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

FORMATE DEHYDROGENASE N FROM E. COLI

Overview

The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a, major component of Escherichia coli nitrate respiration, has been, determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two, heme b groups, and a menaquinone analog. These redox centers are aligned, in a single chain, which extends almost 90 angstroms through the enzyme., The menaquinone reduction site associated with a possible proton pathway, was also characterized. This structure provides critical insights into the, proton motive force generation by redox loop, a common mechanism among a, wide range of respiratory enzymes.

About this Structure

1KQF is a Protein complex structure of sequences from Escherichia coli with 6MO, SF4, MGD, HEM and CDL as ligands. Active as Formate dehydrogenase, with EC number 1.2.1.2 Full crystallographic information is available from OCA.

Reference

Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:11884747

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