2os5

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{{STRUCTURE_2os5| PDB=2os5 | SCENE= }}
{{STRUCTURE_2os5| PDB=2os5 | SCENE= }}
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'''Macrophage migration inhibitory factor from Ancylostoma ceylanicum'''
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===Macrophage migration inhibitory factor from Ancylostoma ceylanicum===
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==Overview==
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Hookworms, parasitic nematodes that infect nearly one billion people worldwide, are a major cause of anemia and malnutrition. We hypothesize that hookworms actively manipulate the host immune response through the production of specific molecules designed to facilitate infection by larval stages and adult worm survival within the intestine. A full-length cDNA encoding a secreted orthologue of the human cytokine, Macrophage Migration Inhibitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum. Elucidation of the three-dimensional crystal structure of recombinant AceMIF (rAceMIF) revealed an overall structural homology with significant differences in the tautomerase sites of the human and hookworm proteins. The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assays of tautomerase activity, macrophage migration, and binding to MIF receptor CD74. The activity of rAceMIF was not inhibited by the ligand ISO-1, which was previously determined to be an inhibitor of the catalytic site of human MIF. These data define unique immunological, structural, and functional characteristics of AceMIF, thereby establishing the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite survival and disease pathogenesis.
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{{ABSTRACT_PUBMED_17567581}}
==About this Structure==
==About this Structure==
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[[Category: Macrophage migration inhibitory factor]]
[[Category: Macrophage migration inhibitory factor]]
[[Category: Nematode]]
[[Category: Nematode]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:33:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:39:02 2008''

Revision as of 17:39, 27 July 2008

Image:2os5.png

Template:STRUCTURE 2os5

Macrophage migration inhibitory factor from Ancylostoma ceylanicum

Template:ABSTRACT PUBMED 17567581

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74., Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M, J Biol Chem. 2007 Aug 10;282(32):23447-56. Epub 2007 Jun 13. PMID:17567581

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