1xo5

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{{STRUCTURE_1xo5| PDB=1xo5 | SCENE= }}
{{STRUCTURE_1xo5| PDB=1xo5 | SCENE= }}
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'''Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein'''
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===Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein===
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==Overview==
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CIB1 (CIB) is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alphaIIbbeta3 integrin and several serine/threonine kinases and potentially modulates their function. The crystal structure for Ca(2+)-bound CIB1 has been determined at 2.0 A resolution and reveals a compact alpha-helical protein containing four EF-hands, the last two of which bind calcium ions in the standard fashion seen in many other EF-hand proteins. CIB1 shares high structural similarity with calcineurin B and the neuronal calcium sensor (NCS) family of EF-hand-containing proteins. Most importantly, like calcineurin B and NCS proteins, which possess a large hydrophobic pocket necessary for ligand binding, CIB1 contains a hydrophobic pocket that has been implicated in ligand binding by previous mutational analysis. However, unlike several NCS proteins, Ca(2+)-bound CIB1 is largely monomeric whether bound to a relevant peptide ligand or ligand-free. Differences in structure, oligomeric state, and phylogeny define a new family of CIB1-related proteins that extends from arthropods to humans.
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{{ABSTRACT_PUBMED_15574431}}
==About this Structure==
==About this Structure==
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[[Category: Ef-hand]]
[[Category: Ef-hand]]
[[Category: Kinase interacting protein]]
[[Category: Kinase interacting protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:40:38 2008''

Revision as of 17:40, 27 July 2008

Image:1xo5.png

Template:STRUCTURE 1xo5

Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein

Template:ABSTRACT PUBMED 15574431

About this Structure

1XO5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins., Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV, J Biol Chem. 2005 Mar 4;280(9):8407-15. Epub 2004 Dec 1. PMID:15574431

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