2qo3

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{{STRUCTURE_2qo3| PDB=2qo3 | SCENE= }}
{{STRUCTURE_2qo3| PDB=2qo3 | SCENE= }}
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'''Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase'''
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===Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase===
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==Overview==
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We report the 2.6 A X-ray crystal structure of a 190 kDa homodimeric fragment from module 3 of the 6-deoxyerthronolide B synthase covalently bound to the inhibitor cerulenin. The structure shows two well-organized interdomain linker regions in addition to the full-length ketosynthase (KS) and acyltransferase (AT) domains. Analysis of the substrate-binding site of the KS domain suggests that a loop region at the homodimer interface influences KS substrate specificity. We also describe a model for the interaction of the catalytic domains with the acyl carrier protein (ACP) domain. The ACP is proposed to dock within a deep cleft between the KS and AT domains, with interactions that span both the KS homodimer and AT domain. In conjunction with other recent data, our results provide atomic resolution pictures of several catalytically relevant protein interactions in this remarkable family of modular megasynthases.
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The line below this paragraph, {{ABSTRACT_PUBMED_17719492}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17719492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17719492}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase., Tang Y, Chen AY, Kim CY, Cane DE, Khosla C, Chem Biol. 2007 Aug;14(8):931-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17719492 17719492]
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase., Tang Y, Chen AY, Kim CY, Cane DE, Khosla C, Chem Biol. 2007 Aug;14(8):931-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17719492 17719492]
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Structure-based dissociation of a type I polyketide synthase module., Chen AY, Cane DE, Khosla C, Chem Biol. 2007 Jul;14(7):784-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17656315 17656315]
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The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase., Tang Y, Kim CY, Mathews II, Cane DE, Khosla C, Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11124-9. Epub 2006 Jul 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16844787 16844787]
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Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase., Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C, Biochemistry. 2004 Nov 9;43(44):13892-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15518537 15518537]
[[Category: Erythronolide synthase]]
[[Category: Erythronolide synthase]]
[[Category: Saccharopolyspora erythraea]]
[[Category: Saccharopolyspora erythraea]]
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[[Category: Ketosynthase]]
[[Category: Ketosynthase]]
[[Category: Phosphopantetheine]]
[[Category: Phosphopantetheine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:16:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:41:34 2008''

Revision as of 17:41, 27 July 2008

Image:2qo3.png

Template:STRUCTURE 2qo3

Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase

Template:ABSTRACT PUBMED 17719492

About this Structure

2QO3 is a Single protein structure of sequence from Saccharopolyspora erythraea. Full crystallographic information is available from OCA.

Reference

Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase., Tang Y, Chen AY, Kim CY, Cane DE, Khosla C, Chem Biol. 2007 Aug;14(8):931-43. PMID:17719492

Structure-based dissociation of a type I polyketide synthase module., Chen AY, Cane DE, Khosla C, Chem Biol. 2007 Jul;14(7):784-92. PMID:17656315

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase., Tang Y, Kim CY, Mathews II, Cane DE, Khosla C, Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11124-9. Epub 2006 Jul 14. PMID:16844787

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase., Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C, Biochemistry. 2004 Nov 9;43(44):13892-8. PMID:15518537

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