2f8k

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[[Image:2f8k.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2f8k| PDB=2f8k | SCENE= }}
{{STRUCTURE_2f8k| PDB=2f8k | SCENE= }}
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'''Sequence specific recognition of RNA hairpins by the SAM domain of Vts1'''
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===Sequence specific recognition of RNA hairpins by the SAM domain of Vts1===
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==Overview==
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The SAM domain of the Saccharomyces cerevisiae post-transcriptional regulator Vts1p epitomizes a subfamily of SAM domains conserved from yeast to humans that function as sequence-specific RNA-binding domains. Here we report the 2.0-A X-ray structure of the Vts1p SAM domain bound to a high-affinity RNA ligand. Specificity of RNA binding arises from the association of a guanosine loop base with a shallow pocket on the SAM domain and from multiple SAM domain contacts to the unique backbone structure of the loop, defined in part by a nonplanar base pair within the loop. We have validated NNF1 as an endogenous target of Vts1p among 79 transcripts that copurify with Vts1p. Bioinformatic analysis of these mRNAs demonstrates that the RNA-binding specificity of Vts1p in vivo is probably more stringent than that of the isolated SAM domain in vitro.
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(as it appears on PubMed at http://www.pubmed.gov), where 16429151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16429151}}
==About this Structure==
==About this Structure==
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[[Category: Sam domain]]
[[Category: Sam domain]]
[[Category: Vts1/rna complex]]
[[Category: Vts1/rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:35:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:44:31 2008''

Revision as of 17:44, 27 July 2008

Image:2f8k.png

Template:STRUCTURE 2f8k

Sequence specific recognition of RNA hairpins by the SAM domain of Vts1

Template:ABSTRACT PUBMED 16429151

About this Structure

2F8K is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p., Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F, Nat Struct Mol Biol. 2006 Feb;13(2):168-76. Epub 2006 Jan 22. PMID:16429151

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