2d0n

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{{STRUCTURE_2d0n| PDB=2d0n | SCENE= }}
{{STRUCTURE_2d0n| PDB=2d0n | SCENE= }}
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'''Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction'''
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===Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction===
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==Overview==
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The Grb2-like adaptor protein GADS is essential for tyrosine kinase-dependent signaling in T lymphocytes. Following T cell receptor ligation, GADS interacts through its C-terminal SH3 domain with the adaptors SLP-76 and LAT, to form a multiprotein signaling complex that is crucial for T cell activation. To understand the structural basis for the selective recognition of GADS by SLP-76, herein is reported the crystal structure at 1.54 Angstrom of the C-terminal SH3 domain of GADS bound to the SLP-76 motif 233-PSIDRSTKP-241, which represents the minimal binding site. In addition to the unique structural features adopted by the bound SLP-76 peptide, the complex structure reveals a unique SH3-SH3 interaction. This homophilic interaction, which is observed in presence of the SLP-76 peptide and is present in solution, extends our understanding of the molecular mechanisms that could be employed by modular proteins to increase their signaling transduction specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 17010654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17010654}}
==About this Structure==
==About this Structure==
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[[Category: Mona/gads sh3c domain]]
[[Category: Mona/gads sh3c domain]]
[[Category: Sh3 domain/complex]]
[[Category: Sh3 domain/complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:28:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:45:59 2008''

Revision as of 17:46, 27 July 2008

Image:2d0n.png

Template:STRUCTURE 2d0n

Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction

Template:ABSTRACT PUBMED 17010654

About this Structure

2D0N is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction., Dimasi N, Int J Biochem Cell Biol. 2007;39(1):109-23. Epub 2006 Aug 12. PMID:17010654

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