This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2dpk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2dpk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2dpk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2dpk| PDB=2dpk | SCENE= }}
{{STRUCTURE_2dpk| PDB=2dpk | SCENE= }}
-
'''The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger'''
+
===The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger===
-
==Overview==
+
<!--
-
The Na+/Ca2+ exchanger is a plasma membrane protein that regulates intracellular Ca2+ levels in cardiac myocytes. Transport activity is governed by Ca2+, and the primary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices. The binding of Ca2+ to the CBD1 sensory domain results in conformational changes that stimulate the exchanger to extrude Ca2+. Here, we present a crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster. This intricate coordination pattern for a Ca2+ binding cluster is indicative of a highly sensitive Ca2+ sensor and may represent a general platform for Ca2+ sensing.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16774926}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16774926 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16774926}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Calcium sensory domain]]
[[Category: Calcium sensory domain]]
[[Category: Cis-proline]]
[[Category: Cis-proline]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:55:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:49:23 2008''

Revision as of 17:49, 27 July 2008

Image:2dpk.png

Template:STRUCTURE 2dpk

The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger

Template:ABSTRACT PUBMED 16774926

About this Structure

2DPK is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif., Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J, J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14. PMID:16774926

Page seeded by OCA on Sun Jul 27 20:49:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dpk"
Personal tools