1urj

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[[Image:1urj.gif|left|200px]]
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{{STRUCTURE_1urj| PDB=1urj | SCENE= }}
{{STRUCTURE_1urj| PDB=1urj | SCENE= }}
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'''SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1'''
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===SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1===
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==Overview==
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All organisms including animal viruses use specific proteins to bind single-stranded DNA rapidly in a non-sequence-specific, flexible, and cooperative manner during the DNA replication process. The crystal structure of a 60-residue C-terminal deletion construct of ICP8, the major single-stranded DNA-binding protein from herpes simplex virus-1, was determined at 3.0 A resolution. The structure reveals a novel fold, consisting of a large N-terminal domain (residues 9-1038) and a small C-terminal domain (residues 1049-1129). On the basis of the structure and the nearest neighbor interactions in the crystal, we have presented a model describing the site of single-stranded DNA binding and explaining the basis for cooperative binding. This model agrees with the beaded morphology observed in electron micrographs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15507432 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15507432}}
==About this Structure==
==About this Structure==
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[[Category: Ssb]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:35:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:52:20 2008''

Revision as of 17:52, 27 July 2008

Image:1urj.png

Template:STRUCTURE 1urj

SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1

Template:ABSTRACT PUBMED 15507432

About this Structure

1URJ is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding., Mapelli M, Panjikar S, Tucker PA, J Biol Chem. 2005 Jan 28;280(4):2990-7. Epub 2004 Oct 26. PMID:15507432

Page seeded by OCA on Sun Jul 27 20:52:20 2008

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