2fxl

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{{STRUCTURE_2fxl| PDB=2fxl | SCENE= }}
{{STRUCTURE_2fxl| PDB=2fxl | SCENE= }}
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'''Urate oxidase from aspergillus flavus complexed with allantoin'''
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===Urate oxidase from aspergillus flavus complexed with allantoin===
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==Overview==
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Urate oxidase from Aspergillus flavus catalyzes the degradation of uric acid to [S]-allantoin through 5-hydroxyisourate as a metastable intermediate. The second degradation step is thought either catalyzed by another specific enzyme, or spontaneous. The structure of the enzyme was known at high resolution by X-ray diffraction of I222 crystals complexed with a purine-type inhibitor (8-azaxanthin). Analyzing the X-ray structure of urate oxidase treated with an excess of urate, the natural substrate, shows unexpectedly that the active site recaptures [S]-allantoin from the racemic end product of a second degradation step.
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(as it appears on PubMed at http://www.pubmed.gov), where 16545381 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16545381}}
==About this Structure==
==About this Structure==
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[[Category: Tunnel-shaped protein]]
[[Category: Tunnel-shaped protein]]
[[Category: Uric acid degradation]]
[[Category: Uric acid degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:53:39 2008''

Revision as of 17:53, 27 July 2008

Image:2fxl.png

Template:STRUCTURE 2fxl

Urate oxidase from aspergillus flavus complexed with allantoin

Template:ABSTRACT PUBMED 16545381

About this Structure

2FXL is a Single protein structure of sequence from Aspergillus flavus. Full crystallographic information is available from OCA.

Reference

Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase., Gabison L, Chiadmi M, Colloc'h N, Castro B, El Hajji M, Prange T, FEBS Lett. 2006 Apr 3;580(8):2087-91. Epub 2006 Mar 10. PMID:16545381

Page seeded by OCA on Sun Jul 27 20:53:39 2008

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