1jwh

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{{STRUCTURE_1jwh| PDB=1jwh | SCENE= }}
{{STRUCTURE_1jwh| PDB=1jwh | SCENE= }}
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'''Crystal Structure of Human Protein Kinase CK2 Holoenzyme'''
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===Crystal Structure of Human Protein Kinase CK2 Holoenzyme===
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==Overview==
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The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 11574463 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11574463}}
==About this Structure==
==About this Structure==
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[[Category: Ck2 holoenzyme]]
[[Category: Ck2 holoenzyme]]
[[Category: Protein kinase ck2]]
[[Category: Protein kinase ck2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:56:41 2008''

Revision as of 17:56, 27 July 2008

Image:1jwh.png

Template:STRUCTURE 1jwh

Crystal Structure of Human Protein Kinase CK2 Holoenzyme

Template:ABSTRACT PUBMED 11574463

About this Structure

1JWH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:11574463

Page seeded by OCA on Sun Jul 27 20:56:41 2008

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