1ni1

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[[Image:1ni1.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ni1| PDB=1ni1 | SCENE= }}
{{STRUCTURE_1ni1| PDB=1ni1 | SCENE= }}
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'''Imidazole and cyanophenyl farnesyl transferase inhibitors'''
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===Imidazole and cyanophenyl farnesyl transferase inhibitors===
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==Overview==
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A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.
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The line below this paragraph, {{ABSTRACT_PUBMED_12699757}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12699757 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12699757}}
==About this Structure==
==About this Structure==
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:33:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:57:08 2008''

Revision as of 17:57, 27 July 2008

Image:1ni1.png

Template:STRUCTURE 1ni1

Imidazole and cyanophenyl farnesyl transferase inhibitors

Template:ABSTRACT PUBMED 12699757

About this Structure

1NI1 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability., Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. PMID:12699757

Page seeded by OCA on Sun Jul 27 20:57:08 2008

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