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1ty7

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[[Image:1ty7.gif|left|200px]]
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{{STRUCTURE_1ty7| PDB=1ty7 | SCENE= }}
{{STRUCTURE_1ty7| PDB=1ty7 | SCENE= }}
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'''Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen'''
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===Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen===
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==Overview==
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Integrins are important adhesion receptors in all Metazoa that transmit conformational change bidirectionally across the membrane. Integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane. Here, we define with crystal structures the atomic basis for allosteric regulation of the conformation and affinity for ligand of the integrin ectodomain, and how fibrinogen-mimetic therapeutics bind to platelet integrin alpha(IIb)beta3. Allostery in the beta3 I domain alters three metal binding sites, associated loops and alpha1- and alpha7-helices. Piston-like displacement of the alpha7-helix causes a 62 degrees reorientation between the beta3 I and hybrid domains. Transmission through the rigidly connected plexin/semaphorin/integrin (PSI) domain in the upper beta3 leg causes a 70 A separation between the knees of the alpha and beta legs. Allostery in the head thus disrupts interaction between the legs in a previously described low-affinity bent integrin conformation, and leg extension positions the high-affinity head far above the cell surface.
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The line below this paragraph, {{ABSTRACT_PUBMED_15378069}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15378069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15378069}}
==About this Structure==
==About this Structure==
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[[Category: Platelet integrin alphaiibbeta3]]
[[Category: Platelet integrin alphaiibbeta3]]
[[Category: Therapeutic antagonism]]
[[Category: Therapeutic antagonism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:02:35 2008''

Revision as of 18:02, 27 July 2008

Image:1ty7.png

Template:STRUCTURE 1ty7

Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen

Template:ABSTRACT PUBMED 15378069

About this Structure

1TY7 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics., Xiao T, Takagi J, Coller BS, Wang JH, Springer TA, Nature. 2004 Nov 4;432(7013):59-67. Epub 2004 Sep 19. PMID:15378069

Page seeded by OCA on Sun Jul 27 21:02:35 2008

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