1rwu

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[[Image:1rwu.gif|left|200px]]
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{{STRUCTURE_1rwu| PDB=1rwu | SCENE= }}
{{STRUCTURE_1rwu| PDB=1rwu | SCENE= }}
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'''Solution structure of conserved protein YbeD from E. coli'''
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===Solution structure of conserved protein YbeD from E. coli===
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==Overview==
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Lipoic acid is an essential prosthetic group in several metabolic pathways. The biosynthetic pathway of protein lipoylation in Escherichia coli involves gene products of the lip operon. YbeD is a conserved bacterial protein located in the dacA-lipB intergenic region. Here, we report the nuclear magnetic resonance structure of YbeD from E. coli. The structure includes a beta alpha beta beta alpha beta fold with two alpha-helices on one side of a four-strand antiparallel beta-sheet. The beta 2-beta 3 loop shows the highest sequence conservation and is likely functionally important. The beta-sheet surface contains a patch of conserved hydrophobic residues, suggesting a role in protein-protein interactions. YbeD shows striking structural homology to the regulatory domain from d-3-phosphoglycerate dehydrogenase, hinting at a role in the allosteric regulation of lipoic acid biosynthesis or the glycine cleavage system.
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{{ABSTRACT_PUBMED_15547281}}
==About this Structure==
==About this Structure==
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1RWU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWU OCA].
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1RWU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RWU OCA].
==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:00:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:05:33 2008''

Revision as of 18:05, 27 July 2008

Image:1rwu.png

Template:STRUCTURE 1rwu

Solution structure of conserved protein YbeD from E. coli

Template:ABSTRACT PUBMED 15547281

About this Structure

1RWU is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structural similarity of YbeD protein from Escherichia coli to allosteric regulatory domains., Kozlov G, Elias D, Semesi A, Yee A, Cygler M, Gehring K, J Bacteriol. 2004 Dec;186(23):8083-8. PMID:15547281

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