1vsc

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[[Image:1vsc.gif|left|200px]]
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{{Seed}}
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[[Image:1vsc.png|left|200px]]
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{{STRUCTURE_1vsc| PDB=1vsc | SCENE= }}
{{STRUCTURE_1vsc| PDB=1vsc | SCENE= }}
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'''VCAM-1'''
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===VCAM-1===
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==Overview==
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Vascular cell adhesion molecule 1 (VCAM-1) represents a structurally and functionally distinct class of immunoglobulin superfamily molecules that bind leukocyte integrins and are involved in inflammatory and immune functions. X-ray crystallography defines the three-dimensional structure of the N-terminal two-domain fragment that participates in ligand binding. Residues in domain 1 important for ligand binding reside in the C-D loop, which projects markedly from one face of the molecule near the contact between domains 1 and 2. A cyclic peptide that mimics this loop inhibits binding of alpha 4 beta 1 integrin-bearing cells to VCAM-1. These data demonstrate how crystallographic structural information can be used to design a small molecule inhibitor of biological function.
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(as it appears on PubMed at http://www.pubmed.gov), where 7539925 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7539925}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:51:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:07:58 2008''

Revision as of 18:08, 27 July 2008

Image:1vsc.png

Template:STRUCTURE 1vsc

VCAM-1

Template:ABSTRACT PUBMED 7539925

About this Structure

1VSC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction., Wang JH, Pepinsky RB, Stehle T, Liu JH, Karpusas M, Browning B, Osborn L, Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5714-8. PMID:7539925

Page seeded by OCA on Sun Jul 27 21:07:58 2008

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