2f1d

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[[Image:2f1d.gif|left|200px]]
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{{STRUCTURE_2f1d| PDB=2f1d | SCENE= }}
{{STRUCTURE_2f1d| PDB=2f1d | SCENE= }}
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'''X-Ray Structure of imidazoleglycerol-phosphate dehydratase'''
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===X-Ray Structure of imidazoleglycerol-phosphate dehydratase===
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==Overview==
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The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution. The structure is composed of 24 identical subunits arranged in 432 symmetry and shows how the formation of a novel dimanganese cluster is crucial to the assembly of the active 24-mer from an inactive trimeric precursor and to the formation of the active site of the enzyme. Molecular modeling suggests that the substrate is bound to the manganese cluster as an imidazolate moiety that subsequently collapses to yield a diazafulvene intermediate. The mode of imidazolate recognition exploits pseudosymmetry at the active site arising from a combination of the assembly of the particle and the pseudosymmetry present in each subunit as a result of gene duplication. This provides an intriguing example of the role of evolution in the design of Nature's catalysts.
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(as it appears on PubMed at http://www.pubmed.gov), where 16338409 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16338409}}
==About this Structure==
==About this Structure==
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[[Category: Manganese]]
[[Category: Manganese]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:10:10 2008''

Revision as of 18:10, 27 July 2008

Image:2f1d.png

Template:STRUCTURE 2f1d

X-Ray Structure of imidazoleglycerol-phosphate dehydratase

Template:ABSTRACT PUBMED 16338409

About this Structure

2F1D is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of imidazoleglycerol-phosphate dehydratase., Glynn SE, Baker PJ, Sedelnikova SE, Davies CL, Eadsforth TC, Levy CW, Rodgers HF, Blackburn GM, Hawkes TR, Viner R, Rice DW, Structure. 2005 Dec;13(12):1809-17. PMID:16338409

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