1nbk

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{{STRUCTURE_1nbk| PDB=1nbk | SCENE= }}
{{STRUCTURE_1nbk| PDB=1nbk | SCENE= }}
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'''The structure of RNA aptamer for HIV Tat complexed with two argininamide molecules'''
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===The structure of RNA aptamer for HIV Tat complexed with two argininamide molecules===
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==Overview==
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An RNA aptamer containing two binding sites exhibits extremely high affinity to the HIV Tat protein. We have determined the structure of the aptamer complexed with two argininamide molecules. Two adjacent U:A:U base triples were formed, which widens the major groove to make space for the two argininamide molecules. The argininamide molecules bind to the G bases through hydrogen bonds. The binding is stabilized through stacking interactions. The structure of the aptamer complexed with a Tat-derived arginine-rich peptide was also characterized. It was suggested that the aptamer structure is similar for both complexes and that the aptamer interacts with two different arginine residues of the peptide simultaneously at the two binding sites, which could explain the high affinity to Tat.
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The line below this paragraph, {{ABSTRACT_PUBMED_12737819}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12737819 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12737819}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBK OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBK OCA].
==Reference==
==Reference==
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[[Category: Rna aptamer]]
[[Category: Rna aptamer]]
[[Category: Rna-ligands complex]]
[[Category: Rna-ligands complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:20:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:11:18 2008''

Revision as of 18:11, 27 July 2008

Image:1nbk.png

Template:STRUCTURE 1nbk

The structure of RNA aptamer for HIV Tat complexed with two argininamide molecules

Template:ABSTRACT PUBMED 12737819

About this Structure

Full experimental information is available from OCA.

Reference

Structural basis of the highly efficient trapping of the HIV Tat protein by an RNA aptamer., Matsugami A, Kobayashi S, Ouhashi K, Uesugi S, Yamamoto R, Taira K, Nishikawa S, Kumar PK, Katahira M, Structure. 2003 May;11(5):533-45. PMID:12737819

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