2tgi

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[[Image:2tgi.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2tgi| PDB=2tgi | SCENE= }}
{{STRUCTURE_2tgi| PDB=2tgi | SCENE= }}
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'''CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY'''
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===CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY===
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==Overview==
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The transforming growth factors-beta (TGF-beta 1 through -beta 5) are a family of homodimeric cytokines that regulate proliferation and function in many cell types. Family members have 66 to 80% sequence identity and nine strictly conserved cysteines. A crystal structure of a member of this family, TGF-beta 2, has been determined at 2.1 angstrom (A) resolution and refined to an R factor of 0.172. The monomer lacks a well-defined hydrophobic core and displays an unusual elongated nonglobular fold with dimensions of approximately 60 A by 20 A by 15 A. Eight cysteines form four intrachain disulfide bonds, which are clustered in a core region forming a network complementary to the network of hydrogen bonds. The dimer is stabilized by the ninth cysteine, which forms an interchain disulfide bond, and by two identical hydrophobic interfaces. Sequence profile analysis of other members of the TGF-beta superfamily, including the activins, inhibins, and several developmental factors, imply that they also adopt the TGF-beta fold.
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The line below this paragraph, {{ABSTRACT_PUBMED_1631557}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1631557 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1631557}}
==About this Structure==
==About this Structure==
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[[Category: Davies, D R.]]
[[Category: Davies, D R.]]
[[Category: Growth factor]]
[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:23:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:12:38 2008''

Revision as of 18:12, 27 July 2008

Image:2tgi.png

Template:STRUCTURE 2tgi

CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY

Template:ABSTRACT PUBMED 1631557

About this Structure

2TGI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily., Daopin S, Piez KA, Ogawa Y, Davies DR, Science. 1992 Jul 17;257(5068):369-73. PMID:1631557

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