2nos

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{{STRUCTURE_2nos| PDB=2nos | SCENE= }}
{{STRUCTURE_2nos| PDB=2nos | SCENE= }}
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'''MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), AMINOGUANIDINE COMPLEX'''
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===MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), AMINOGUANIDINE COMPLEX===
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==Overview==
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The nitric oxide synthase oxygenase domain (NOSox) oxidizes arginine to synthesize the cellular signal and defensive cytotoxin nitric oxide (NO). Crystal structures determined for cytokine-inducible NOSox reveal an unusual fold and heme environment for stabilization of activated oxygen intermediates key for catalysis. A winged beta sheet engenders a curved alpha-beta domain resembling a baseball catcher's mitt with heme clasped in the palm. The location of exposed hydrophobic residues and the results of mutational analysis place the dimer interface adjacent to the heme-binding pocket. Juxtaposed hydrophobic O2- and polar L-arginine-binding sites occupied by imidazole and aminoguanidine, respectively, provide a template for designing dual-function inhibitors and imply substrate-assisted catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 9334294 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9334294}}
==About this Structure==
==About this Structure==
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[[Category: No]]
[[Category: No]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:15:35 2008''

Revision as of 18:15, 27 July 2008

Image:2nos.png

Template:STRUCTURE 2nos

MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), AMINOGUANIDINE COMPLEX

Template:ABSTRACT PUBMED 9334294

About this Structure

2NOS is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes., Crane BR, Arvai AS, Gachhui R, Wu C, Ghosh DK, Getzoff ED, Stuehr DJ, Tainer JA, Science. 1997 Oct 17;278(5337):425-31. PMID:9334294

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