2vjf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2vjf", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:2vjf.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2vjf.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2vjf| PDB=2vjf | SCENE= }}
{{STRUCTURE_2vjf| PDB=2vjf | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE MDM2-MDMX RING DOMAIN HETERODIMER'''
+
===CRYSTAL STRUCTURE OF THE MDM2-MDMX RING DOMAIN HETERODIMER===
-
==Overview==
+
<!--
-
MDM2, a ubiquitin E3-ligase of the RING family, has a key role in regulating p53 abundance. During normal non-stress conditions p53 is targeted for degradation by MDM2. MDM2 can also target itself and MDMX for degradation. MDMX is closely related to MDM2 but the RING domain of MDMX does not possess intrinsic E3-ligase activity. Instead, MDMX regulates p53 abundance by modulating the levels and activity of MDM2. Dimerization, mediated by the conserved C-terminal RING domains of both MDM2 and MDMX, is critical to this activity. Here we report the crystal structure of the MDM2/MDMX RING domain heterodimer and map residues required for functional interaction with the E2 (UbcH5b). In both MDM2 and MDMX residues C-terminal to the RING domain have a key role in dimer formation. In addition we show that these residues are part of an extended surface that is essential for ubiquitylation in trans. This study provides a molecular basis for understanding how heterodimer formation leads to stabilization of MDM2, yet degradation of p53, and suggests novel targets for therapeutic intervention.Cell Death and Differentiation (2008) 15, 841-848; doi:10.1038/sj.cdd.4402309; published online 25 January 2008.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18219319}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18219319 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18219319}}
==About this Structure==
==About this Structure==
Line 40: Line 44:
[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:26:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:16:32 2008''

Revision as of 18:16, 27 July 2008

Image:2vjf.png

Template:STRUCTURE 2vjf

CRYSTAL STRUCTURE OF THE MDM2-MDMX RING DOMAIN HETERODIMER

Template:ABSTRACT PUBMED 18219319

About this Structure

2VJF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans., Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL, Cell Death Differ. 2008 May;15(5):841-8. Epub 2008 Jan 25. PMID:18219319

Page seeded by OCA on Sun Jul 27 21:16:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vjf"
Personal tools