1v1k

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[[Image:1v1k.gif|left|200px]]
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{{STRUCTURE_1v1k| PDB=1v1k | SCENE= }}
{{STRUCTURE_1v1k| PDB=1v1k | SCENE= }}
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'''CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR'''
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===CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR===
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==Overview==
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Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.
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(as it appears on PubMed at http://www.pubmed.gov), where 12941311 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12941311}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:58:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:16:37 2008''

Revision as of 18:16, 27 July 2008

Image:1v1k.png

Template:STRUCTURE 1v1k

CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR

Template:ABSTRACT PUBMED 12941311

About this Structure

1V1K is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1h06. Full crystallographic information is available from OCA.

Reference

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines., Beattie JF, Breault GA, Ellston RP, Green S, Jewsbury PJ, Midgley CJ, Naven RT, Minshull CA, Pauptit RA, Tucker JA, Pease JE, Bioorg Med Chem Lett. 2003 Sep 15;13(18):2955-60. PMID:12941311

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