2a2p

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[[Image:2a2p.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2a2p| PDB=2a2p | SCENE= }}
{{STRUCTURE_2a2p| PDB=2a2p | SCENE= }}
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'''Solution structure of SelM from Mus musculus'''
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===Solution structure of SelM from Mus musculus===
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==Overview==
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Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system. Selenium-containing proteins, which incorporate this essential micronutrient as selenocysteine, are proposed to mediate the positive effects of dietary selenium. Presented here are the solution NMR structures of the selenoprotein SelM and an ortholog of the selenoprotein Sep15. These data reveal that Sep15 and SelM are structural homologs that establish a new thioredoxin-like protein family. The location of the active-site redox motifs within the fold together with the observed localized conformational changes after thiol-disulfide exchange and measured redox potential indicate that they have redox activity. In mammals, Sep15 expression is regulated by dietary selenium, and either decreased or increased expression of this selenoprotein alters redox homeostasis. A physiological role for Sep15 and SelM as thiol-disulfide oxidoreductases and their contribution to the quality control pathways of the endoplasmic reticulum are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 16319061 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16319061}}
==About this Structure==
==About this Structure==
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2A2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2P OCA].
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2A2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2P OCA].
==Reference==
==Reference==
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[[Category: Redox enzyme]]
[[Category: Redox enzyme]]
[[Category: Selenoprotein]]
[[Category: Selenoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:31:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:17:51 2008''

Revision as of 18:17, 27 July 2008

Image:2a2p.png

Template:STRUCTURE 2a2p

Solution structure of SelM from Mus musculus

Template:ABSTRACT PUBMED 16319061

About this Structure

2A2P is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family., Ferguson AD, Labunskyy VM, Fomenko DE, Arac D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J, J Biol Chem. 2006 Feb 10;281(6):3536-43. Epub 2005 Nov 30. PMID:16319061

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