2b5v

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{{STRUCTURE_2b5v| PDB=2b5v | SCENE= }}
{{STRUCTURE_2b5v| PDB=2b5v | SCENE= }}
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'''Crystal structure of glucose dehydrogenase from Haloferax mediterranei'''
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===Crystal structure of glucose dehydrogenase from Haloferax mediterranei===
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==Overview==
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The structure of glucose dehydrogenase from the extreme halophile Haloferax mediterranei has been solved at 1.6-A resolution under crystallization conditions which closely mimic the "in vivo" intracellular environment. The decoration of the enzyme's surface with acidic residues is only partially neutralized by bound potassium counterions, which also appear to play a role in substrate binding. The surface shows the expected reduction in hydrophobic character, surprisingly not from changes associated with the loss of exposed hydrophobic residues but rather arising from a loss of lysines consistent with the genome wide-reduction of this residue in extreme halophiles. The structure reveals a highly ordered, multilayered solvation shell that can be seen to be organized into one dominant network covering much of the exposed surface accessible area to an extent not seen in almost any other protein structure solved. This finding is consistent with the requirement of the enzyme to form a protective shell in a dehydrating environment.
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(as it appears on PubMed at http://www.pubmed.gov), where 16551747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16551747}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei., Britton KL, Baker PJ, Fisher M, Ruzheinikov S, Gilmour DJ, Bonete MJ, Ferrer J, Pire C, Esclapez J, Rice DW, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4846-51. Epub 2006 Mar 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16551747 16551747]
Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei., Britton KL, Baker PJ, Fisher M, Ruzheinikov S, Gilmour DJ, Bonete MJ, Ferrer J, Pire C, Esclapez J, Rice DW, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4846-51. Epub 2006 Mar 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16551747 16551747]
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Crystallization and preliminary X-ray analysis of glucose dehydrogenase from Haloferax mediterranei., Ferrer J, Fisher M, Burke J, Sedelnikova SE, Baker PJ, Gilmour DJ, Bonete MJ, Pire C, Esclapez J, Rice DW, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1887-9. Epub 2001, Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11717506 11717506]
[[Category: Glucose 1-dehydrogenase]]
[[Category: Glucose 1-dehydrogenase]]
[[Category: Haloferax mediterranei]]
[[Category: Haloferax mediterranei]]
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[[Category: Ruzheinikov, S.]]
[[Category: Ruzheinikov, S.]]
[[Category: Nucleotide binding motif]]
[[Category: Nucleotide binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:53:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:22:11 2008''

Revision as of 18:22, 27 July 2008

Image:2b5v.png

Template:STRUCTURE 2b5v

Crystal structure of glucose dehydrogenase from Haloferax mediterranei

Template:ABSTRACT PUBMED 16551747

About this Structure

2B5V is a Single protein structure of sequence from Haloferax mediterranei. Full crystallographic information is available from OCA.

Reference

Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei., Britton KL, Baker PJ, Fisher M, Ruzheinikov S, Gilmour DJ, Bonete MJ, Ferrer J, Pire C, Esclapez J, Rice DW, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4846-51. Epub 2006 Mar 21. PMID:16551747

Crystallization and preliminary X-ray analysis of glucose dehydrogenase from Haloferax mediterranei., Ferrer J, Fisher M, Burke J, Sedelnikova SE, Baker PJ, Gilmour DJ, Bonete MJ, Pire C, Esclapez J, Rice DW, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1887-9. Epub 2001, Nov 21. PMID:11717506

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