1ssk

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{{STRUCTURE_1ssk| PDB=1ssk | SCENE= }}
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'''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''
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===Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein===
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==Overview==
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The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
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(as it appears on PubMed at http://www.pubmed.gov), where 15147189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15147189}}
==About this Structure==
==About this Structure==
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1SSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].
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1SSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].
==Reference==
==Reference==
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[[Category: Yu, L.]]
[[Category: Yu, L.]]
[[Category: Nucleocapsid protein]]
[[Category: Nucleocapsid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:05:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:22:20 2008''

Revision as of 18:22, 27 July 2008

Image:1ssk.png

Template:STRUCTURE 1ssk

Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein

Template:ABSTRACT PUBMED 15147189

About this Structure

1SSK is a Single protein structure of sequence from Human sars coronavirus. Full experimental information is available from OCA.

Reference

Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein., Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET, Biochemistry. 2004 May 25;43(20):6059-63. PMID:15147189

Page seeded by OCA on Sun Jul 27 21:22:20 2008

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