2fq3

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{{STRUCTURE_2fq3| PDB=2fq3 | SCENE= }}
{{STRUCTURE_2fq3| PDB=2fq3 | SCENE= }}
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'''Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes'''
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===Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes===
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==Overview==
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The SWIRM domain is a module found in the Swi3 and Rsc8 subunits of SWI/SNF-family chromatin remodeling complexes, and the Ada2 and BHC110/LSD1 subunits of chromatin modification complexes. Here we report the high-resolution crystal structure of the SWIRM domain from Swi3 and characterize the in vitro and in vivo function of the SWIRM domains from Saccharomyces cerevisiae Swi3 and Rsc8. The Swi3 SWIRM forms a four-helix bundle containing a pseudo 2-fold axis and a helix-turn-helix motif commonly found in DNA-binding proteins. We show that the Swi3 SWIRM binds free DNA and mononucleosomes with high and comparable affinity and that a subset of Swi3 substitution mutants that display growth defects in vivo also show impaired DNA-binding activity in vitro, consistent with a nucleosome targeting function of this domain. Genetic and biochemical studies also reveal that the Rsc8 and Swi3 SWIRM domains are essential for the proper assembly and in vivo functions of their respective complexes. Together, these studies identify the SWIRM domain as an essential multifunctional module for the regulation of gene expression.
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==About this Structure==
==About this Structure==
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[[Category: Zhao, K.]]
[[Category: Zhao, K.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:11:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:31:15 2008''

Revision as of 18:31, 27 July 2008

Image:2fq3.png

Template:STRUCTURE 2fq3

Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes

Template:ABSTRACT PUBMED 16461455

About this Structure

2FQ3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes., Da G, Lenkart J, Zhao K, Shiekhattar R, Cairns BR, Marmorstein R, Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2057-62. Epub 2006 Feb 3. PMID:16461455

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