2b1e

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{{Seed}}
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{{STRUCTURE_2b1e| PDB=2b1e | SCENE= }}
{{STRUCTURE_2b1e| PDB=2b1e | SCENE= }}
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'''The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif'''
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===The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif===
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==Overview==
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The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Here we present the structures of the Exo70p subunit of this complex and of the C-terminal domains of Exo84p, at 2.0-A and 2.85-A resolution, respectively. Exo70p forms a 160-A-long rod with a novel fold composed of contiguous alpha-helical bundles. The Exo84p C terminus also forms a long rod (80 A), which unexpectedly has the same fold as the Exo70p N terminus. Our structural results and our experimental observations concerning the interaction between Exo70p and other exocyst subunits or Rho3p GTPase are consistent with an architecture wherein exocyst subunits are composed of mostly helical modules strung together into long rods.
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(as it appears on PubMed at http://www.pubmed.gov), where 16249794 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16249794}}
==About this Structure==
==About this Structure==
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[[Category: Exocyst]]
[[Category: Exocyst]]
[[Category: Tethering complex]]
[[Category: Tethering complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:44:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:31:32 2008''

Revision as of 18:31, 27 July 2008

Image:2b1e.png

Template:STRUCTURE 2b1e

The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif

Template:ABSTRACT PUBMED 16249794

About this Structure

2B1E is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif., Dong G, Hutagalung AH, Fu C, Novick P, Reinisch KM, Nat Struct Mol Biol. 2005 Dec;12(12):1094-100. Epub 2005 Oct 26. PMID:16249794

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