1k40

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[[Image:1k40.gif|left|200px]]
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{{STRUCTURE_1k40| PDB=1k40 | SCENE= }}
{{STRUCTURE_1k40| PDB=1k40 | SCENE= }}
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'''crystal structure of the FAT domain of focal adhesion kinase'''
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===crystal structure of the FAT domain of focal adhesion kinase===
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==Overview==
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Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. We have determined the crystal structure of FAT and show that it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. We show by mutagenesis that paxillin binding involves two hydrophobic patches on opposite faces of the bundle and propose a model in which two LD motifs of paxillin adopt amphipathic helices that augment the hydrophobic core of FAT, creating a six-helix bundle.
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(as it appears on PubMed at http://www.pubmed.gov), where 11799401 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11799401}}
==About this Structure==
==About this Structure==
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[[Category: Vuori, K.]]
[[Category: Vuori, K.]]
[[Category: Helix bundle]]
[[Category: Helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:16:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:34:03 2008''

Revision as of 18:34, 27 July 2008

Image:1k40.png

Template:STRUCTURE 1k40

crystal structure of the FAT domain of focal adhesion kinase

Template:ABSTRACT PUBMED 11799401

About this Structure

1K40 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:11799401

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