2r6g

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[[Image:2r6g.jpg|left|200px]]
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{{STRUCTURE_2r6g| PDB=2r6g | SCENE= }}
{{STRUCTURE_2r6g| PDB=2r6g | SCENE= }}
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'''The Crystal Structure of the E. coli Maltose Transporter'''
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===The Crystal Structure of the E. coli Maltose Transporter===
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==Overview==
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The maltose uptake system of Escherichia coli is a well-characterized member of the ATP-binding cassette transporter superfamily. Here we present the 2.8-A crystal structure of the intact maltose transporter in complex with the maltose-binding protein, maltose and ATP. This structure, stabilized by a mutation that prevents ATP hydrolysis, captures the ATP-binding cassette dimer in a closed, ATP-bound conformation. Maltose is occluded within a solvent-filled cavity at the interface of the two transmembrane subunits, about halfway into the lipid bilayer. The binding protein docks onto the entrance of the cavity in an open conformation and serves as a cap to ensure unidirectional translocation of the sugar molecule. These results provide direct evidence for a concerted mechanism of transport in which solute is transferred from the binding protein to the transmembrane subunits when the cassette dimer closes to hydrolyse ATP.
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(as it appears on PubMed at http://www.pubmed.gov), where 18033289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18033289}}
==About this Structure==
==About this Structure==
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[[Category: Sugar transport]]
[[Category: Sugar transport]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:19:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:34:28 2008''

Revision as of 18:34, 27 July 2008

Image:2r6g.png

Template:STRUCTURE 2r6g

The Crystal Structure of the E. coli Maltose Transporter

Template:ABSTRACT PUBMED 18033289

About this Structure

2R6G is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a catalytic intermediate of the maltose transporter., Oldham ML, Khare D, Quiocho FA, Davidson AL, Chen J, Nature. 2007 Nov 22;450(7169):515-21. PMID:18033289

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