2gb1

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[[Image:2gb1.gif|left|200px]]
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{{STRUCTURE_2gb1| PDB=2gb1 | SCENE= }}
{{STRUCTURE_2gb1| PDB=2gb1 | SCENE= }}
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'''A NOVEL, HIGHLY STABLE FOLD OF THE IMMUNOGLOBULIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G'''
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===A NOVEL, HIGHLY STABLE FOLD OF THE IMMUNOGLOBULIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G===
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==Overview==
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The high-resolution three-dimensional structure of a single immunoglobulin binding domain (B1, which comprises 56 residues including the NH2-terminal Met) of protein G from group G Streptococcus has been determined in solution by nuclear magnetic resonance spectroscopy on the basis of 1058 experimental restraints. The average atomic root-mean-square distribution about the mean coordinate positions is 0.27 angstrom (A) for the backbone atoms, 0.65 A for all atoms, and 0.39 A for atoms excluding disordered surface side chains. The structure has no disulfide bridges and is composed of a four-stranded beta sheet, on top of which lies a long helix. The central two strands (beta 1 and beta 4), comprising the NH2- and COOH-termini, are parallel, and the outer two strands (beta 2 and beta 3) are connected by the helix in a +3x crossover. This novel topology (-1, +3x, -1), coupled with an extensive hydrogen-bonding network and a tightly packed and buried hydrophobic core, is probably responsible for the extreme thermal stability of this small domain (reversible melting at 87 degrees C).
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The line below this paragraph, {{ABSTRACT_PUBMED_1871600}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1871600 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1871600}}
==About this Structure==
==About this Structure==
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2GB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GB1 OCA].
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2GB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GB1 OCA].
==Reference==
==Reference==
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[[Category: Gronenborn, A M.]]
[[Category: Gronenborn, A M.]]
[[Category: Immunoglobulin binding protein]]
[[Category: Immunoglobulin binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:54:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:34:39 2008''

Revision as of 18:34, 27 July 2008

Image:2gb1.png

Template:STRUCTURE 2gb1

A NOVEL, HIGHLY STABLE FOLD OF THE IMMUNOGLOBULIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G

Template:ABSTRACT PUBMED 1871600

About this Structure

2GB1 is a Single protein structure of sequence from Bacteria. Full experimental information is available from OCA.

Reference

A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G., Gronenborn AM, Filpula DR, Essig NZ, Achari A, Whitlow M, Wingfield PT, Clore GM, Science. 1991 Aug 9;253(5020):657-61. PMID:1871600

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