2ixe

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[[Image:2ixe.gif|left|200px]]
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{{Seed}}
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[[Image:2ixe.png|left|200px]]
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{{STRUCTURE_2ixe| PDB=2ixe | SCENE= }}
{{STRUCTURE_2ixe| PDB=2ixe | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TAP1 WITH ATP (D645N MUTANT)'''
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===CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TAP1 WITH ATP (D645N MUTANT)===
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==Overview==
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The ABC transporter associated with antigen processing (TAP) shuttles cytosolic peptides into the endoplasmic reticulum for loading onto class I MHC molecules. Transport is fueled by ATP binding and hydrolysis at two distinct cytosolic ATPase sites. One site comprises consensus motifs shared among most ABC transporters, while the second has substituted, degenerate motifs. Biochemical and crystallography experiments with a TAP cytosolic domain demonstrate that the consensus ATPase site has high catalytic activity and facilitates ATP-dependent dimerization of the cytosolic domains, which is an important conformational change during transport. In contrast, the degenerate site is defective in dimerization and ATP hydrolysis. Full-length TAP mutagenesis demonstrates the necessity for at least one consensus site, supporting our conclusion that the consensus site is the principal facilitator of substrate transport. Since asymmetry of the ATPase site motifs is a feature of many mammalian homologs, our proposed model has broad implications for ABC transporters.
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(as it appears on PubMed at http://www.pubmed.gov), where 17018292 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17018292}}
==About this Structure==
==About this Structure==
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[[Category: Abc atpase]]
[[Category: Abc atpase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:02:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:34:50 2008''

Revision as of 18:34, 27 July 2008

Image:2ixe.png

Template:STRUCTURE 2ixe

CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TAP1 WITH ATP (D645N MUTANT)

Template:ABSTRACT PUBMED 17018292

About this Structure

2IXE is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter., Procko E, Ferrin-O'Connell I, Ng SL, Gaudet R, Mol Cell. 2006 Oct 6;24(1):51-62. PMID:17018292

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