1ydp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ydp.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ydp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ydp| PDB=1ydp | SCENE= }}
{{STRUCTURE_1ydp| PDB=1ydp | SCENE= }}
-
'''1.9A crystal structure of HLA-G'''
+
===1.9A crystal structure of HLA-G===
-
==Overview==
+
<!--
-
HLA-G is a nonclassical major histocompatibility complex class I (MHC-I) molecule that is primarily expressed at the fetal-maternal interface, where it is thought to play a role in protecting the fetus from the maternal immune response. HLA-G binds a limited repertoire of peptides and interacts with the inhibitory leukocyte Ig-like receptors LIR-1 and LIR-2 and possibly with certain natural killer cell receptors. To gain further insights into HLA-G function, we determined the 1.9-A structure of a monomeric HLA-G complexed to a natural endogenous peptide ligand from histone H2A (RIIPRHLQL). An extensive network of contacts between the peptide and the antigen-binding cleft reveal a constrained mode of binding reminiscent of the nonclassical HLA-E molecule, thereby providing a structural basis for the limited peptide repertoire of HLA-G. The alpha3 domain of HLA-G, a candidate binding site for the LIR-1 and -2 inhibitory receptors, is structurally distinct from the alpha3 domains of classical MHC-I molecules, providing a rationale for the observed affinity differences for these ligands. The structural data suggest a head-to-tail mode of dimerization, mediated by an intermolecular disulfide bond, that is consistent with the observation of HLA-G dimers on the cell surface.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15718280}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15718280 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15718280}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Rossjohn, J.]]
[[Category: Rossjohn, J.]]
[[Category: Immune system]]
[[Category: Immune system]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:11:48 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:35:46 2008''

Revision as of 18:35, 27 July 2008

Image:1ydp.png

Template:STRUCTURE 1ydp

1.9A crystal structure of HLA-G

Template:ABSTRACT PUBMED 15718280

About this Structure

1YDP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface., Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, McCluskey J, Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3360-5. Epub 2005 Feb 17. PMID:15718280

Page seeded by OCA on Sun Jul 27 21:35:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ydp"
Personal tools