1zm0

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[[Image:1zm0.gif|left|200px]]
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{{STRUCTURE_1zm0| PDB=1zm0 | SCENE= }}
{{STRUCTURE_1zm0| PDB=1zm0 | SCENE= }}
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'''Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms'''
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===Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms===
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==Overview==
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Pleckstrin is an important intracellular protein involved in the phosphoinositide-signalling pathways of platelet activation. This protein contains both N- and C-terminal pleckstrin-homology (PH) domains (N-PH and C-PH). The crystal structure of C-PH was solved by molecular replacement and refined at 2.1 Angstroms resolution. Two molecules were observed within the asymmetric unit and it is proposed that the resulting dimer interface could contribute to the previously observed oligomerization of pleckstrin in resting platelets. Structural comparisons between the phosphoinositide-binding loops of the C-PH crystal structure and the PH domains of DAPP1 and TAPP1, the N-terminal PH domain of pleckstrin and a recently described solution structure of C-PH are presented and discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 16510979 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16510979}}
==About this Structure==
==About this Structure==
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[[Category: Ph domain]]
[[Category: Ph domain]]
[[Category: Pleckstrin]]
[[Category: Pleckstrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:47:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:36:08 2008''

Revision as of 18:36, 27 July 2008

Image:1zm0.png

Template:STRUCTURE 1zm0

Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms

Template:ABSTRACT PUBMED 16510979

About this Structure

1ZM0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms., Jackson SG, Zhang Y, Bao X, Zhang K, Summerfield R, Haslam RJ, Junop MS, Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):324-30. Epub 2006, Feb 22. PMID:16510979

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