1zuw

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[[Image:1zuw.gif|left|200px]]
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{{Seed}}
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[[Image:1zuw.png|left|200px]]
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{{STRUCTURE_1zuw| PDB=1zuw | SCENE= }}
{{STRUCTURE_1zuw| PDB=1zuw | SCENE= }}
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'''Crystal structure of B.subtilis glutamate racemase (RacE) with D-Glu'''
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===Crystal structure of B.subtilis glutamate racemase (RacE) with D-Glu===
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==Overview==
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D-glutamate is an essential building block of the peptidoglycan layer in bacterial cell walls and can be synthesized from L-glutamate by glutamate racemase (RacE). The structure of a complex of B. subtilis RacE with D-glutamate reveals that the glutamate is buried in a deep pocket, whose formation at the interface of the enzyme's two domains involves a large-scale conformational rearrangement. These domains are related by pseudo-2-fold symmetry, which superimposes the two catalytic cysteine residues, which are located at equivalent positions on either side of the alpha carbon of the substrate. The structural similarity of these two domains suggests that the racemase activity of RacE arose as a result of gene duplication. The structure of the complex is dramatically different from that proposed previously and provides new insights into the RacE mechanism and an explanation for the potency of a family of RacE inhibitors, which have been developed as novel antibiotics.
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The line below this paragraph, {{ABSTRACT_PUBMED_16271894}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16271894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16271894}}
==About this Structure==
==About this Structure==
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[[Category: Glutamate racemase]]
[[Category: Glutamate racemase]]
[[Category: Peptidoglycan biosynthesis]]
[[Category: Peptidoglycan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:06:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:37:33 2008''

Revision as of 18:37, 27 July 2008

Image:1zuw.png

Template:STRUCTURE 1zuw

Crystal structure of B.subtilis glutamate racemase (RacE) with D-Glu

Template:ABSTRACT PUBMED 16271894

About this Structure

1ZUW is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Substrate-induced conformational changes in Bacillus subtilis glutamate racemase and their implications for drug discovery., Ruzheinikov SN, Taal MA, Sedelnikova SE, Baker PJ, Rice DW, Structure. 2005 Nov;13(11):1707-13. PMID:16271894

Page seeded by OCA on Sun Jul 27 21:37:33 2008

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