1u63

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[[Image:1u63.gif|left|200px]]
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{{STRUCTURE_1u63| PDB=1u63 | SCENE= }}
{{STRUCTURE_1u63| PDB=1u63 | SCENE= }}
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'''THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX'''
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===THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX===
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==Overview==
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The RNA-binding ability of ribosomal protein L1 is of profound interest since the protein has a dual function as a ribosomal protein binding rRNA and as a translational repressor binding its mRNA. Here, we report the crystal structure of ribosomal protein L1 in complex with a specific fragment of its mRNA and compare it with the structure of L1 in complex with a specific fragment of 23S rRNA determined earlier. In both complexes, a strongly conserved RNA structural motif is involved in L1 binding through a conserved network of RNA-protein H-bonds inaccessible to the solvent. These interactions should be responsible for specific recognition between the protein and RNA. A large number of additional non-conserved RNA-protein H-bonds stabilizes both complexes. The added contribution of these non-conserved H-bonds makes the ribosomal complex much more stable than the regulatory one.
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The line below this paragraph, {{ABSTRACT_PUBMED_15659579}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15659579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15659579}}
==About this Structure==
==About this Structure==
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[[Category: Ribosomal protein]]
[[Category: Ribosomal protein]]
[[Category: Ribosome]]
[[Category: Ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:48:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:39:44 2008''

Revision as of 18:39, 27 July 2008

Image:1u63.png

Template:STRUCTURE 1u63

THE STRUCTURE OF A RIBOSOMAL PROTEIN L1-mRNA COMPLEX

Template:ABSTRACT PUBMED 15659579

About this Structure

1U63 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Ribosomal protein L1 recognizes the same specific structural motif in its target sites on the autoregulatory mRNA and 23S rRNA., Nevskaya N, Tishchenko S, Gabdoulkhakov A, Nikonova E, Nikonov O, Nikulin A, Platonova O, Garber M, Nikonov S, Piendl W, Nucleic Acids Res. 2005 Jan 19;33(2):478-85. Print 2005. PMID:15659579

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