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2qij

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[[Image:2qij.jpg|left|200px]]
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{{STRUCTURE_2qij| PDB=2qij | SCENE= }}
{{STRUCTURE_2qij| PDB=2qij | SCENE= }}
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'''Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.'''
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===Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.===
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==Overview==
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Hepatitis B core (HBc) particles have been extensively exploited as carriers for foreign immunological epitopes in the development of multicomponent vaccines and diagnostic reagents. Crystals of the T = 4 HBc particle were grown in PEG 20,000, ammonium sulfate and various types of alcohols. A temperature jump from 277 or 283 to 290 K was found to enhance crystal growth. A crystal grown using MPD as a cryoprotectant diffracted X-rays to 7.7 A resolution and data were collected to 99.6% completeness at 8.9 A. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 352.3, b = 465.5, c = 645.0 A. The electron-density map reveals a protrusion that is consistent with the N-terminus extending out from the surface of the capsid. The structure presented here supports the idea that N-terminal insertions can be exploited in the development of diagnostic reagents, multicomponent vaccines and delivery vehicles into mammalian cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 17671358 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17671358}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Viral capsid protein]]
[[Category: Viral capsid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:01:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:41:01 2008''

Revision as of 18:41, 27 July 2008

Image:2qij.png

Template:STRUCTURE 2qij

Hepatitis B Capsid Protein with an N-terminal extension modelled into 8.9 A data.

Template:ABSTRACT PUBMED 17671358

About this Structure

2QIJ is a Single protein structure of sequence from Hepatitis b virus subtype adyw. Full crystallographic information is available from OCA.

Reference

Crystallization and X-ray analysis of the T = 4 particle of hepatitis B capsid protein with an N-terminal extension., Tan WS, McNae IW, Ho KL, Walkinshaw MD, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):642-7. Epub 2007 Jul 21. PMID:17671358

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