1pl6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pl6.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pl6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pl6| PDB=1pl6 | SCENE= }}
{{STRUCTURE_1pl6| PDB=1pl6 | SCENE= }}
-
'''Human SDH/NADH/inhibitor complex'''
+
===Human SDH/NADH/inhibitor complex===
-
==Overview==
+
<!--
-
Sorbitol dehydrogenase (hSDH) and aldose reductase form the polyol pathway that interconverts glucose and fructose. Redox changes from overproduction of the coenzyme NADH by SDH may play a role in diabetes-induced dysfunction in sensitive tissues, making SDH a therapeutic target for diabetic complications. We have purified and determined the crystal structures of human SDH alone, SDH with NAD(+), and SDH with NADH and an inhibitor that is competitive with fructose. hSDH is a tetramer of identical, catalytically active subunits. In the apo and NAD(+) complex, the catalytic zinc is coordinated by His69, Cys44, Glu70, and a water molecule. The inhibitor coordinates the zinc through an oxygen and a nitrogen atom with the concomitant dissociation of Glu70. The inhibitor forms hydrophobic interactions to NADH and likely sterically occludes substrate binding. The structure of the inhibitor complex provides a framework for developing more potent inhibitors of hSDH.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12962626}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12962626 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12962626}}
==About this Structure==
==About this Structure==
Line 42: Line 46:
[[Category: Cp-166,572]]
[[Category: Cp-166,572]]
[[Category: Sorbitol dehydrogenase]]
[[Category: Sorbitol dehydrogenase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:12:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:51:20 2008''

Revision as of 18:51, 27 July 2008

Image:1pl6.png

Template:STRUCTURE 1pl6

Human SDH/NADH/inhibitor complex

Template:ABSTRACT PUBMED 12962626

About this Structure

1PL6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase., Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL, Structure. 2003 Sep;11(9):1071-85. PMID:12962626

Page seeded by OCA on Sun Jul 27 21:51:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pl6"
Personal tools