2za2

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{{STRUCTURE_2za2| PDB=2za2 | SCENE= }}
{{STRUCTURE_2za2| PDB=2za2 | SCENE= }}
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'''Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum'''
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===Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum===
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==Overview==
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Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we report the X-ray analysis of apo, substrate or product-complex forms of OMPDC from Plasmodium falciparum (PfOMPDC) at 2.7, 2.65 and 2.65 A, respectively. The structural analysis provides the substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site. The structural basis of substrate or product binding to PfOMPDC will help to uncover the decarboxylation mechanism and facilitate structure-based optimization of antimalarial drugs.
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==About this Structure==
==About this Structure==
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Pyrimidine biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:05:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:52:51 2008''

Revision as of 18:52, 27 July 2008

Image:2za2.png

Template:STRUCTURE 2za2

Crystal Structure of the apo-form of orotidine-5'-monophosphate decarboxylase from P.falciparum

Template:ABSTRACT PUBMED 17981823

About this Structure

2ZA2 is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:17981823

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