3hsc
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(New page: 200px<br /><applet load="3hsc" size="450" color="white" frame="true" align="right" spinBox="true" caption="3hsc, resolution 1.93Å" /> '''THREE-DIMENSIONAL ST...)
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Revision as of 17:39, 20 November 2007
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THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
Overview
The three-dimensional structure of the amino-terminal 44K ATPase fragment, of the 70K bovine heat-shock cognate protein has been solved to a, resolution of 2.2 A. The ATPase fragment has two structural lobes with a, deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary, structure similar to that of hexokinase, although the remainder of the, structures of the two proteins are completely dissimilar, suggesting that, both the phosphotransferase mechanism and the substrate-induced, conformational change intrinsic to the hexokinases may be used by the 70K, heat shock-related proteins.
About this Structure
3HSC is a Single protein structure of sequence from Bos taurus with MG, PO4, NA and ADP as ligands. This structure superseeds the now removed PDB entries 2HSC and 1HSC. Active as Adenosinetriphosphatase, with EC number 3.6.1.3 Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562
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