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1p79

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{{STRUCTURE_1p79| PDB=1p79 | SCENE= }}
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'''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex'''
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===Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex===
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==Overview==
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Bulges are an important structural motif in RNA and can be used as recognition and interaction sites in RNA-protein interaction and RNA-RNA interaction. Here we report the first crystal structure of a bulged RNA tetraplex at 1.1 A resolution. The hexamer r(U)(BrdG)r(UGGU) forms a parallel tetraplex with the uridine sandwiched by guanines bulging out. The bulged uridine adopts the syn glycosidic conformation and its O2 and N3 atoms face outwards, serving as an effective recognition and interaction site. The bulge formation both widens the groove width and changes the groove hydrogen-bonding pattern on its 5' side. However, the bulge does not make any bends or kinks in the tetraplex structure. The present study demonstrates the dramatic difference between uridine and guanine in forming tetraplex structure. In addition, both G(syn) tetrad and G(anti) tetrad have been observed. They display the same base-pairing pattern and similar C1'-C1' distance but different hydrogen-bonding patterns in the groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 14604532 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14604532}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetraplex]]
[[Category: Tetraplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:57:47 2008''

Revision as of 18:58, 27 July 2008

Image:1p79.png

Template:STRUCTURE 1p79

Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex

Template:ABSTRACT PUBMED 14604532

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:14604532

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