2p1l

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[[Image:2p1l.gif|left|200px]]
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{{Seed}}
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[[Image:2p1l.png|left|200px]]
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{{STRUCTURE_2p1l| PDB=2p1l | SCENE= }}
{{STRUCTURE_2p1l| PDB=2p1l | SCENE= }}
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'''Structure of the Bcl-XL:Beclin 1 complex'''
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===Structure of the Bcl-XL:Beclin 1 complex===
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==Overview==
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Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor Beclin 1 has been proposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-X(L). However, the molecular basis for this interaction remains enigmatic. Here we report that Beclin 1 contains a conserved BH3 domain, which is both necessary and sufficient for its interaction with Bcl-X(L). We also report the crystal structure of a Beclin BH3 peptide in complex with Bcl-X(L) at 2.5A resolution. Reminiscent of previously determined Bcl-X(L)-BH3 structures, the amphipathic BH3 helix of Beclin 1 bound to a conserved hydrophobic groove of Bcl-X(L). These results define Beclin 1 as a novel BH3-only protein, implying that Beclin 1 may have a direct role in initiating apoptotic signaling. We propose that this putative apoptotic function may be linked to the ability of Beclin 1 to suppress tumor formation in mammals.
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The line below this paragraph, {{ABSTRACT_PUBMED_17337444}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17337444 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17337444}}
==About this Structure==
==About this Structure==
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[[Category: Beclin]]
[[Category: Beclin]]
[[Category: Bh3 domain]]
[[Category: Bh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:08:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:19:58 2008''

Revision as of 19:20, 27 July 2008

Image:2p1l.png

Template:STRUCTURE 2p1l

Structure of the Bcl-XL:Beclin 1 complex

Template:ABSTRACT PUBMED 17337444

About this Structure

2P1L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein., Oberstein A, Jeffrey PD, Shi Y, J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2. PMID:17337444

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