1xt8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xt8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xt8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xt8| PDB=1xt8 | SCENE= }}
{{STRUCTURE_1xt8| PDB=1xt8 | SCENE= }}
-
'''Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution'''
+
===Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution===
-
==Overview==
+
<!--
-
Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain-Barre syndrome. C. jejuni is asaccharolytic because it lacks an active glycolytic pathway for the use of sugars as a carbon source. This suggests an increased reliance on amino acids as nutrients and indeed the genome sequence of this organism indicates the presence of a number of amino acid uptake systems. Cj0982, also known as CjaA, is a putative extracytoplasmic solute receptor for one such uptake system as well as a major surface antigen and vaccine candidate. The crystal structure of Cj0982 reveals a two-domain protein with density in the enclosed cavity between the domains that clearly defines the presence of a bound cysteine ligand. Fluorescence titration experiments were used to demonstrate that Cj0982 binds cysteine tightly and specifically with a K(d) of approximately 10(-7) M consistent with a role as a receptor for a high-affinity transporter. These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15948956}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15948956 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15948956}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:14:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:26:35 2008''

Revision as of 19:26, 27 July 2008

Image:1xt8.png

Template:STRUCTURE 1xt8

Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution

Template:ABSTRACT PUBMED 15948956

About this Structure

1XT8 is a Single protein structure of sequence from Campylobacter jejuni. Full crystallographic information is available from OCA.

Reference

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein., Muller A, Thomas GH, Horler R, Brannigan JA, Blagova E, Levdikov VM, Fogg MJ, Wilson KS, Wilkinson AJ, Mol Microbiol. 2005 Jul;57(1):143-55. PMID:15948956

Page seeded by OCA on Sun Jul 27 22:26:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xt8"
Personal tools