2ff4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ff4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ff4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ff4| PDB=2ff4 | SCENE= }}
{{STRUCTURE_2ff4| PDB=2ff4 | SCENE= }}
-
'''Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide'''
+
===Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide===
-
==Overview==
+
<!--
-
Ser/Thr phosphorylation has emerged as a critical regulatory mechanism in a number of bacteria, including Mycobacterium tuberculosis. This problematic pathogen encodes 11 eukaryotic-like Ser/Thr kinases, yet few substrates or signaling targets have been characterized. Here, we report the structure of EmbR (2.0 A), a putative transcriptional regulator of key arabinosyltransferases (EmbC, -A, and -B), and an endogenous substrate of the Ser/Thr-kinase PknH. EmbR presents a unique domain architecture: the N-terminal winged-helix DNA-binding domain forms an extensive interface with the all-helical central bacterial transcriptional activation domain and is positioned adjacent to the regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a Thr-phosphorylated site in PknH. The structure in complex with a phospho-peptide (1.9 A) reveals a conserved mode of phospho-threonine recognition by the FHA domain and evidence for specific recognition of the cognate kinase. The present structures suggest hypotheses as to how EmbR might propagate the phospho-relay signal from its cognate kinase, while serving as a template for the structurally uncharacterized Streptomyces antibiotic regulatory protein family of transcription factors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16477027}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16477027 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16477027}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Tetratricopeptide repeat]]
[[Category: Tetratricopeptide repeat]]
[[Category: Winged-helix]]
[[Category: Winged-helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:49:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:28:01 2008''

Revision as of 19:28, 27 July 2008

Image:2ff4.png

Template:STRUCTURE 2ff4

Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide

Template:ABSTRACT PUBMED 16477027

About this Structure

2FF4 is a Protein complex structure of sequences from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis., Alderwick LJ, Molle V, Kremer L, Cozzone AJ, Dafforn TR, Besra GS, Futterer K, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2558-63. Epub 2006 Feb 13. PMID:16477027

Page seeded by OCA on Sun Jul 27 22:28:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ff4"
Personal tools